Distinct receptor activity modifying protein ( RAMP ) domains differentially modulate interaction with calcitonin receptors
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چکیده
243 Introduction 474 Discussion 1165 Non standard abbreviations: AMY, amylin receptor phenotype; CGRP, calcitonin gene-related peptide; CLR, calcitonin receptor-like receptor; CT, calcitonin; CTR, calcitonin receptor; GPCR, G protein-coupled receptor; HA, haemagglutinin epitope tag; hCT, human calcitonin; RAMP, receptor activity modifying protein; rAmy, rat amylin; sCT, salmon calcitonin; TMD, transmembrane domain. This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on March 10, 2006 as DOI: 10.1124/mol.105.021915 at A PE T Jornals on Jne 0, 2017 m oharm .aspeurnals.org D ow nladed from
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Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors.
Calcitonin receptors (CTRs) dimerize with receptor activity-modifying proteins (RAMPs) to generate high-affinity amylin (AMY) receptors; however, the relative contribution of individual RAMP domains to the formation of AMY receptors is poorly understood. We have used chimeras between RAMP1 and RAMP2 that specifically exchanged the N-terminal, transmembrane, or C-terminal domain and examined the...
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